high serum levels of rheumatoid factor and anti-phosphatidylserine antibody in patients with ischemic heart disease

Authors

abdollah jafarzadeh

department of immunology masoud poorgholami

department of internal medicine, medical school, rafsanjan university of medical sciences, rafsanjan, iran maryam nemati

department of immunology mohammad-taghi rezayati

department of immunology

abstract

background: immunopathological and inflammatory processes play important roles in the initiation and development of ischemic heart disease (ihd). objective: the aim of this study was to evaluate the serum levels of several autoantibodies including rheumatoid factor (rf), anti-nuclear antibodies (ana), anti-small nuclear ribonucleoprotein (anti-sm), anti-phosphatidylserine (anti-ps) and anti-cardiolipin (anti-cl) antibodies in patients with ihd. methods: a total of 120 patients with ihd with acute myocardial infarction (ami; n=60) or unstable angina (ua; n=60) and 60 sex- and age-matched healthy subjects were enrolled in this study. serum samples of participants were tested for the ana, anti-sm, anti-ps and anti-cl antibodies by elisa. serum level of rf was measured by a turbidometric method. results: the mean serum levels of rf and anti-ps antibodies in ami group and ua group were significantly higher than those observed in the control group (p

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Journal title:
iranian journal of immunology

جلد ۸، شماره ۱، صفحات ۳۴-۴۴

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